Phenotypes Associated with This Genotype

Genotype
MGI:5440264

• Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}; St14^tm1Bug/St14⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:188121 )

• lethality at E10.5-E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:188121 )

• survive longer than embryos homozygous for Spint2^{Gt(KST272)Byg} alone

• lethality at E10.5-E14.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:188121 )

• 45% of embryos die at E9.5 or earlier

embryo

spina bifida ( J:188121 )

• in 95-100% of mice

abnormal placenta morphology ( J:188121 )

• placental defects

abnormal placenta labyrinth morphology ( J:188121 )

• incomplete differentiation

limbs/digits/tail

curly tail ( J:188121 )

• in 89% of mice

nervous system

spina bifida ( J:188121 )

• in 95-100% of mice

exencephaly ( J:188121 )

• in 11% of mice