Phenotypes Associated with This Genotype

Genotype
MGI:5440263

• Allelic Composition: Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}; St14^tm1Bug/St14^tm1Bug
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:188121 )

N • embryos are viable unlike embryos homozygous for Spint2^{Gt(KST272)Byg} alone

embryo

embryo phenotype ( J:188121 )

N • inactivation of St14 rescues defects in placental development seen in mice homozygous for Spint2^{Gt(KST272)Byg} alone

abnormal neural tube morphology ( J:188121 )

spina bifida ( J:188121 )

• in 18% of mice

• partial rescue compared to mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous for St14^tm1Bug

limbs/digits/tail

curly tail ( J:188121 )

• in 62% of mice

nervous system

abnormal neural tube morphology ( J:188121 )

spina bifida ( J:188121 )

• in 18% of mice

• partial rescue compared to mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous for St14^tm1Bug

exencephaly ( J:188121 )

• in 13% of mice