Phenotypes Associated with This Genotype

Genotype
MGI:5440261

• Allelic Composition: Prss8^{Gt(IST10122F12)Tigm}/Prss8^{Gt(IST10122F12)Tigm}
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:188121 )

• mice die within 48 hours after birth

homeostasis/metabolism

dehydration ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

impaired skin barrier function ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

integument

impaired skin barrier function ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

abnormal epidermis stratum corneum morphology ( J:188121 )

• stratum corneum is completely compacted, presenting with few intercorneocyte lacunae

• 18% reduction in the thickness of the stratum corneum