Analysis Tools
immune system
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• triple mutants exhibit reduced lupus-like phenotypes compared to Traf3ip2 single homozygotes, with normal spleen weight and cellularity, normal B cell numbers (B cell numbers however are decreased compared to Tcrb and Tcrd double homozygous mutants), normal cervical lymph node weight and cellularity, significantly less total IgG antibodies and anti-nuclear antigen specific IgG autoantibodies, and no IgG deposition in the kidney glomeruli
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• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
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• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
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• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels of anti-chromatin IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels anti-dsDNA IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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• serum levels of anti-histone IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
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hematopoietic system
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• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
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• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
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• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
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• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
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• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes
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cardiovascular system
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• kidneys show occasional obstruction of the capillary lumina
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renal/urinary system
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• kidneys show occasional obstruction of the capillary lumina
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• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease
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• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
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cellular
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• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease
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