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Phenotypes Associated with This Genotype
Genotype
MGI:5440181
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Cdx1-cre)23Kem/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (47 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (47 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Tg(Cdx1-cre)23Kem mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• develop until birth but do not survive

embryo
N
• at E9.5 the length of tail buds are similar to controls
• abnormally folded distally at E9.5

renal/urinary system
• at E14.5
• at E14.5

reproductive system
• at E14.5
• small gonads at E14.5

limbs/digits/tail
• deformed shortened forelimb digits vertebrae at E18.5
• at E18.5
• at E18.5
• at E18.5 in rare cases some rudimentary upper hindlimb bones are present
• at E14.5
• at E14.5

skeleton
• at E18.5
• deformed shortened fused ribs at E18.5
• at E18.5
• at E18.5
• deformed shortened fused vertebrae at E18.5
• at E18.5
• at E18.5

digestive/alimentary system
• at E14.5

nervous system
• abnormally folded distally at E9.5

endocrine/exocrine glands
• small gonads at E14.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory