Phenotypes Associated with This Genotype

Genotype
MGI:5440072

• Allelic Composition: Braf^tm2Cpri/Braf⁺; Tg(CMV-cre)1Cgn/0
• Genetic Background: B6.Cg-Braf^tm2Cpri Tg(CMV-cre)1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187371 )

• only 70% of mice survive to adulthood with some mice lost after weaning

cardiovascular system

increased myocardial fiber size ( J:187371 )

thick interventricular septum ( J:187371 )

enlarged heart ( J:187371 )

cardiac hypertrophy ( J:187371 )

thick ventricular wall ( J:187371 )

immune system

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

lymphoid hyperplasia ( J:187371 )

• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks

neoplasm

increased intestinal adenoma incidence ( J:187371 )

• one mouse exhibits small intestinal adenoma at 79 weeks

increased skin papilloma incidence ( J:187371 )

• predisposition in aged mice

vision/eye

abnormal eye morphology ( J:187371 )

• including cataracts and watery eyes in some mice

cataract ( J:187371 )

• in some mice

craniofacial

abnormal facial morphology ( J:187371 )

• facial dysmorphia

long incisors ( J:187371 )

• in some mice

growth/size/body

enlarged heart ( J:187371 )

cardiac hypertrophy ( J:187371 )

abnormal facial morphology ( J:187371 )

• facial dysmorphia

long incisors ( J:187371 )

• in some mice

decreased body weight ( J:187371 )

decreased body height ( J:187371 )

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

muscle

increased myocardial fiber size ( J:187371 )

nervous system

increased susceptibility to ischemic brain injury ( J:187371 )

• in some mice

reproductive system

abnormal myometrium morphology ( J:187371 )

• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks

uterus prolapse ( J:187371 )

• in some mice

digestive/alimentary system

intestine polyps ( J:187371 )

• predisposition in aged mice

increased intestinal adenoma incidence ( J:187371 )

• one mouse exhibits small intestinal adenoma at 79 weeks

hematopoietic system

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

integument

increased skin papilloma incidence ( J:187371 )

• predisposition in aged mice

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:187371 )

• in some mice

skeleton

long incisors ( J:187371 )

• in some mice