Phenotypes Associated with This Genotype

Genotype
MGI:5439978

• Allelic Composition: Nlrc3^tm1Bhk/Nlrc3^tm1Bhk
• Genetic Background: B6.129S6-Nlrc3^tm1Bhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased monocyte cell number ( J:187586 )

• slightly greater frequency of peritoneal monocytes in LPS-treated mice

increased circulating interleukin-6 level ( J:187586 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:187586 )

• in LPS-treated mice

increased tumor necrosis factor secretion ( J:187586 )

• from macrophages in response to TLR agonists that activate signaling via the Myd88-dependent pathway

• however, response to agonists that activate signaling via the TRIF-dependent pathway is normal

increased susceptibility to endotoxin shock ( J:187586 )

• LPS-treated mice exhibit delayed recovery as determined by lower body weight and temperature compared with wild-type mice

homeostasis/metabolism

increased circulating interleukin-6 level ( J:187586 )

• in LPS-treated mice

increased circulating tumor necrosis factor level ( J:187586 )

• in LPS-treated mice

decreased body temperature ( J:187586 )

• in LPS-treated mice after 18 to 42 hours

growth/size/body

decreased body weight ( J:187586 )

• in LPS-treated mice after 18 to 42 hours

hematopoietic system

increased monocyte cell number ( J:187586 )

• slightly greater frequency of peritoneal monocytes in LPS-treated mice