Phenotypes Associated with This Genotype

Genotype
MGI:5439825

• Allelic Composition: Psen1^tm1.1Ruvi/Psen1^tm1.1Ruvi; Tg(APP)8.9Btla/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:187475 )

• in the cerebral cortex with amyloid deposition

microgliosis ( J:187475 )

• keratan sulfate-positive-activated microglia

amyloid beta deposits ( J:187475 )

• scarce small plaques in the hippocampus of young animals becoming more prominent with age

• small and scattered plaques at 6 months in the cerebral cortex

• prominent plaques with age in the neocortex and leptomeninges

• small and moderate sized plaques in the cerebral cortex

• parenchymal amyloid deposition in the cerebellum of older mice

neurodegeneration ( J:187475 )

• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles

immune system

microgliosis ( J:187475 )

• keratan sulfate-positive-activated microglia

hematopoietic system

microgliosis ( J:187475 )

• keratan sulfate-positive-activated microglia

homeostasis/metabolism

amyloid beta deposits ( J:187475 )

• scarce small plaques in the hippocampus of young animals becoming more prominent with age

• small and scattered plaques at 6 months in the cerebral cortex

• prominent plaques with age in the neocortex and leptomeninges

• small and moderate sized plaques in the cerebral cortex

• parenchymal amyloid deposition in the cerebellum of older mice

cellular

astrocytosis ( J:187475 )

• in the cerebral cortex with amyloid deposition

microgliosis ( J:187475 )

• keratan sulfate-positive-activated microglia