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Phenotypes Associated with This Genotype
Genotype
MGI:5439368
Allelic
Composition		 Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Rnf43tm1Cle mutation (0 available); any Rnf43 mutation (36 available)
Znrf3tm1Cle mutation (0 available); any Znrf3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:186765 )
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells

digestive/alimentary system
increased intestinal adenoma incidence ( J:186765 )
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory