Phenotypes Associated with This Genotype

Genotype
MGI:5439284

• Allelic Composition: Spaca1^tm1.1Osb/Spaca1^tm1.1Osb; Tg(Acr-EGFP)1Osb/0
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:187685 )

♂ • abnormalities in acrosome formation are detected in spermatids at around step 6

abnormal acrosome morphology ( J:187685 )

♂ • all round-headed testicular and cauda epididymal spermatozoa have an acrosome of negligible size

♂ • a few spermatozoa have small aberrantly shaped acrosomes

globozoospermia ( J:187685 )

♂

abnormal spermatid morphology ( J:187685 )

♂ • as around step 6 nuclei are smaller and accumulation of GFP in the acrosomal granule is not apparent

cellular

abnormal acrosome morphology ( J:187685 )

♂ • all round-headed testicular and cauda epididymal spermatozoa have an acrosome of negligible size

♂ • a few spermatozoa have small aberrantly shaped acrosomes

globozoospermia ( J:187685 )

♂

abnormal spermatid morphology ( J:187685 )

♂ • as around step 6 nuclei are smaller and accumulation of GFP in the acrosomal granule is not apparent