Phenotypes Associated with This Genotype

Genotype
MGI:5439283

• Allelic Composition: Spaca1^tm1.1Osb/Spaca1^tm1.1Osb
• Genetic Background: involves: 129S2/SvPas * C57BL * C57BL/6N * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:187685 )

♂ • abnormalities become more apparent as the spermatozoa pass through the epididymis

abnormal sperm flagellum morphology ( J:187685 )

♂ • ectopic localization in mature spermatozoa

coiled sperm flagellum ( J:187685 )

♂ • spermatozoa from the cauda epididymidis show a tail coiled around the head

abnormal sperm head morphology ( J:187685 )

♂ • mature spermatozoa have disorganized mitochondria trapped inside large cytoplasmic droplets and misshapen nuclei

abnormal acrosome morphology ( J:187685 )

♂ • hypoplasia of the intermediate filament bundles in round spermatids

globozoospermia ( J:187685 )

♂ • all testicular spermatozoa show a round-headed morphology

asthenozoospermia ( J:187685 )

♂ • impaired spematozoa swimming ability

male infertility ( J:187685 )

♂ • males, but not females, are sterile

♂ • when fertilization is accomplished by intracytoplasmic sperm injection healthy pups can be produced

cellular

teratozoospermia ( J:187685 )

♂ • abnormalities become more apparent as the spermatozoa pass through the epididymis

abnormal sperm flagellum morphology ( J:187685 )

♂ • ectopic localization in mature spermatozoa

coiled sperm flagellum ( J:187685 )

♂ • spermatozoa from the cauda epididymidis show a tail coiled around the head

abnormal sperm head morphology ( J:187685 )

♂ • mature spermatozoa have disorganized mitochondria trapped inside large cytoplasmic droplets and misshapen nuclei

abnormal acrosome morphology ( J:187685 )

♂ • hypoplasia of the intermediate filament bundles in round spermatids

globozoospermia ( J:187685 )

♂ • all testicular spermatozoa show a round-headed morphology

asthenozoospermia ( J:187685 )

♂ • impaired spematozoa swimming ability