Phenotypes Associated with This Genotype

Genotype
MGI:5438985

• Allelic Composition: Del(3Gbp2-ps-Gbp5)1Ktak/Del(3Gbp2-ps-Gbp5)1Ktak
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:187397 )

• in mice infected with T. gondii

immune system

immune system phenotype ( J:187397 )

N • mice exhibit normal susceptibility to Listeria monocytogenes-induced mortality

increased susceptibility to parasitic infection ( J:187397 )

• mice infected with Toxoplasma gondii exhibit increased spreading and proliferation of T. gondii and increased mortality compared with wild-type mice

• mouse embryonic fibroblasts and macrophage exhibit impaired IFN-gamma-induced reduction of T. gondii infection compared with wild-type cells

• macrophages of T. gondii-infected mice exhibit impaired IFN-gamma-mediated anti-T. gondii response (nitric oxide-dependent), disruption of parasitophorous vacuole (PV) membrane and Irgb6 recruitment of PV compared with wild-type cells

• however, mice exhibit normal T cell response and production of IL12 and IFN-gamma

increased susceptibility to parasitic infection induced morbidity/mortality ( J:187397 )

• in mice infected with T. gondii