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Phenotypes Associated with This Genotype
Genotype
MGI:5438959
Allelic
Composition
Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation (0 available); any Prox1 mutation (50 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice
• at P28, mossy cells are reduced in the hilus compared to in control mice
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory