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Phenotypes Associated with This Genotype
Genotype
MGI:5438958
Allelic
Composition		 Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre)20Kmik/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation (0 available); any Prox1 mutation (49 available)
Tg(Camk2a-cre)20Kmik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dentate gyrus morphology ( J:187615 )
• the dentate gyrus is small due to apoptosis from leaky cre expression
• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells
abnormal hippocampus CA4 region morphology ( J:187615 )
• at P28, mossy cells are reduced in the hilus compared to in control mice
abnormal hippocampus granule cell morphology ( J:187615 )
• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/16/2026
MGI 6.24 		The Jackson Laboratory