Phenotypes Associated with This Genotype

Genotype
MGI:5438801

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0
• Genetic Background: involves: C3H/HeJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:185792 )

• Background Sensitivity: granule cell layer of the dentate gyrus is reduced and disorganized in 2 month old mice as compared to non-transgenic controls and the C57BL/6 congenic background

• Background Sensitivity: cell loss is not observed in 2 week old mice

• Background Sensitivity: width of granule cell layer is 42% thinner than controls by 2-4 months

• Background Sensitivity: width of granule cell layer is 68% thinner than controls by 6-9 months

• however, when mice are reared on doxycycline, cell loss is not observed

hippocampal neuron degeneration ( J:185792 )

• neuronal degeneration is progressive