Phenotypes Associated with This Genotype

Genotype
MGI:5438792

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0
• Genetic Background: (B6.Cg-Tg(Camk2a-tTA)1Mmay x FVB/NJ)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:185792 )

• Background Sensitivity: width of dentate gyrus granule cell layer is 21% thinner than controls and the C57BL/6 congenic background

• however, doxycycline administered in the first 6 weeks of life protects against cell loss

hippocampal neuron degeneration ( J:185792 )

• Background Sensitivity: width of dentate gyrus granule cell layer is 21% thinner than controls and the C57BL/6 congenic background

• however, doxycycline administered in the first 6 weeks of life protects against cell loss