Phenotypes Associated with This Genotype

Genotype
MGI:5438789

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0
• Genetic Background: (B6.Cg-Tg(Camk2a-tTA)1Mmay x 129X1/SvJ)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:185792 )

• Background Sensitivity: freezing in response to unsignaled foot shock decreases in mutant and increases in control during final minutes of 5 minute test

nervous system

abnormal dentate gyrus morphology ( J:185792 )

• Background Sensitivity: width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background

hippocampal neuron degeneration ( J:185792 )

• Background Sensitivity: width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background