Phenotypes for Mfge8 Timd4 MGI:5438221 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mfge8^tm1Osa/Mfge8^tm1Osa Timd4^tm1Osa/Timd4^tm1Osa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8^tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
Timd4^tm1Osa mutation (1 available); any Timd4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage phagocytosis ( J:187181 )

increased anti-nuclear antigen antibody level ( J:187181 )

• by 30 weeks of age in female mice

• at 7 weeks after anti-Tnfa antibody treatment in female mice

• however, male mice exhibit normal autoantibody levels

increased anti-double stranded DNA antibody level ( J:187181 )

• by 30 weeks of age in female mice

• however, male mice exhibit normal autoantibody levels

hematopoietic system

impaired macrophage phagocytosis ( J:187181 )

cellular

impaired macrophage phagocytosis ( J:187181 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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