Phenotypes Associated with This Genotype

Genotype
MGI:5438037

• Allelic Composition: Sh2d1a^tm1Vei/Sh2d1a^tm1Vei
• Genetic Background: B6.129-Sh2d1a^tm1Vei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell physiology ( J:187430 )

• NK cells exhibit severely decreased killing of hematopoietic cells RMA-S, YAC-1 and MHC class I-deficient splenocytes in vitro compared with wild-type cells

• mice exhibit a 5-fold increase in residual RMA-S cells in the peritoneal cavity compared with wild-type mice

• when 2B4 is engaged, the activating effect is inhibited compared to on wild-type cells

• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells

• defects are not as severe as in Sh2d1a^tm1Pls homozygotes

• however, response to hamster CHO cells is normal

decreased interferon-gamma secretion ( J:187430 )

hematopoietic system

abnormal NK cell physiology ( J:187430 )

• NK cells exhibit severely decreased killing of hematopoietic cells RMA-S, YAC-1 and MHC class I-deficient splenocytes in vitro compared with wild-type cells

• mice exhibit a 5-fold increase in residual RMA-S cells in the peritoneal cavity compared with wild-type mice

• when 2B4 is engaged, the activating effect is inhibited compared to on wild-type cells

• NK cells exhibit reduced conjugation with RMA-S cells compared with wild-type cells

• defects are not as severe as in Sh2d1a^tm1Pls homozygotes

• however, response to hamster CHO cells is normal