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Phenotypes Associated with This Genotype
Genotype
MGI:5437687
Allelic
Composition
Ceacam16tm1Wzm/Ceacam16tm1Wzm
Genetic
Background
BALB/cJ-Ceacam16tm1Wzm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ceacam16tm1Wzm mutation (1 available); any Ceacam16 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• young mice exhibit increased hearing threshold at low and high frequency stimulation with reduced signal strength and waviness of waveform compared with wild-type mice (J:187537)
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice (J:187537)
• however, mice exhibit normal hearing threshold with click stimuli or multi-frequency click stimulus (J:187537)
• young mice exhibit increased hearing threshold at low and high frequency stimulation with reduced signal strength and waviness of waveform compared with wild-type mice (J:187537)
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice (J:187537)
• however, mice exhibit normal hearing threshold with click stimuli or multi-frequency click stimulus (J:187537)
• at 1 to 2 months, mice stimulated with 50 db sound pressure level (L1) exhibit reduced 2f1 to f2 distortion product otoacoustic emission amplitude compared with wild-type mice (J:187537)
• aged mice exhibit reduced threshold compared with wild-type mice (J:187537)
• however, evoking threshold sound pressure level is normal (J:187537)
• at 1 to 2 months, mice stimulated with 50 db sound pressure level (L1) exhibit reduced 2f1 to f2 distortion product otoacoustic emission amplitude compared with wild-type mice (J:187537)
• aged mice exhibit reduced threshold compared with wild-type mice (J:187537)
• however, evoking threshold sound pressure level is normal (J:187537)
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice (J:187537)
• however, mice exhibit normal vulnerability to noise exposure and age-related progression of hearing loss (J:187537)
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice (J:187537)
• however, mice exhibit normal vulnerability to noise exposure and age-related progression of hearing loss (J:187537)

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Dominant 4A; DFNA4A 600652 J:187537


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory