Phenotypes Associated with This Genotype

Genotype
MGI:5437687

• Allelic Composition: Ceacam16^tm1Wzm/Ceacam16^tm1Wzm
• Genetic Background: BALB/cJ-Ceacam16^tm1Wzm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:187537 )

• young mice exhibit increased hearing threshold at low and high frequency stimulation with reduced signal strength and waviness of waveform compared with wild-type mice

• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice

• however, mice exhibit normal hearing threshold with click stimuli or multi-frequency click stimulus

decreased distortion product otoacoustic emission amplitude ( J:187537 )

• at 1 to 2 months, mice stimulated with 50 db sound pressure level (L1) exhibit reduced 2f1 to f2 distortion product otoacoustic emission amplitude compared with wild-type mice

decreased distortion product otoacoustic emission threshold ( J:187537 )

• aged mice exhibit reduced threshold compared with wild-type mice

• however, mice exhibit normal hearing threshold with click stimuli or multi-frequency click stimulus

nonsyndromic hearing loss ( J:187537 )

• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice

• however, mice exhibit normal vulnerability to noise exposure and age-related progression of hearing loss

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant nonsyndromic deafness 4A		DOID:0110573	OMIM:600652	J:187537