Mouse Genome Informatics
hm
    Ceacam16tm1Wzm/Ceacam16tm1Wzm
BALB/cJ-Ceacam16tm1Wzm
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hearing/vestibular/ear
• young mice exhibit increased hearing threshold at low and high frequency stimulation with reduced signal strength and waviness of waveform compared with wild-type mice
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice
• however, mice exhibit normal hearing threshold with click stimuli or multi-frequency click stimulus
• at 1 to 2 months, mice stimulated with 50 db sound pressure level (L1) exhibit reduced 2f1 to f2 distortion product otoacoustic emission amplitude compared with wild-type mice
• aged mice exhibit reduced threshold compared with wild-type mice
• however, evoking threshold sound pressure level is normal
• aged mice exhibit increased hearing threshold for click, noise and pure tone stimuli 2 to 8 kHz compared with wild-type mice
• however, mice exhibit normal vulnerability to noise exposure and age-related progression of hearing loss

Mouse Models of Human Disease
OMIM IDRef(s)
Deafness, Autosomal Dominant 4A; DFNA4A 600652 J:187537