Phenotypes Associated with This Genotype

Genotype
MGI:5437327

• Allelic Composition: Stat5a^tm1.1Wjl/Stat5a^tm1.1Wjl; Stat5b^tm2.1Wjl/Stat5b^tm2.1Wjl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:187325 )

• in CD8+ T cells following IL2 withdrawal

decreased T cell proliferation ( J:187325 )

• induced by cytokines or LCMV

• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal

abnormal leukocyte morphology ( J:187325 )

• slight increase in splenic B to T cell ratio compared to in control mice

• however, total numbers are normal

decreased NK cell number ( J:187325 )

abnormal T cell subpopulation ratio ( J:187325 )

• the ratio of CD4 to CD8 is modestly increased compared to in control mice

decreased CD8-positive, alpha-beta T cell number ( J:187325 )

• slight

abnormal regulatory T cell physiology ( J:187325 )

• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells

cellular

increased T cell apoptosis ( J:187325 )

• in CD8+ T cells following IL2 withdrawal

decreased T cell proliferation ( J:187325 )

• induced by cytokines or LCMV

• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal

hematopoietic system

increased T cell apoptosis ( J:187325 )

• in CD8+ T cells following IL2 withdrawal

decreased T cell proliferation ( J:187325 )

• induced by cytokines or LCMV

• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal

decreased erythrocyte cell number ( J:187325 )

• in neonates but not adults

decreased hematocrit ( J:187325 )

• in neonates but not adults

decreased hemoglobin content ( J:187325 )

• in neonates but not adults

abnormal leukocyte morphology ( J:187325 )

• slight increase in splenic B to T cell ratio compared to in control mice

• however, total numbers are normal

decreased NK cell number ( J:187325 )

abnormal T cell subpopulation ratio ( J:187325 )

• the ratio of CD4 to CD8 is modestly increased compared to in control mice

decreased CD8-positive, alpha-beta T cell number ( J:187325 )

• slight

abnormal regulatory T cell physiology ( J:187325 )

• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells