Phenotypes Associated with This Genotype

Genotype
MGI:5437219

• Allelic Composition: Cd40lg^tm1Imx/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:103954 )

• reduced shear induced platelet aggregation

• reduced in vitro platelet aggregation

abnormal thrombosis ( J:103954 )

• significantly delayed blood vessel occlusion

increased bleeding time ( J:103954 )

• significantly prolonged tail vein bleeding times

hematopoietic system

hematopoietic system phenotype ( J:103954 )

N • normal platelet counts

decreased platelet aggregation ( J:103954 )

• reduced shear induced platelet aggregation

• reduced in vitro platelet aggregation

cardiovascular system

abnormal vascular endothelial cell morphology ( J:115587 )

• carotid artery intimal thickening is increased over controls 21 days after collar placement around the carotid artery