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Phenotypes Associated with This Genotype
Genotype
MGI:5436439
Allelic
Composition
Adartm2Knk/Adar+
Genetic
Background
chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Knk mutation (0 available); any Adar mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no live embryos after E14.5
• some 90% chimeric embryos survive to E12.5-E13.5
• embryos normal up to E11.5

hematopoietic system
• more than 90% of circulating erythrocytes remain nucleated
• some circulating erythrocytes undergo mitosis

liver/biliary system
• "lacy" appearance of livers at E12.5-E13.5
• hematopoietic islands are present

embryo
• more than 90% of circulating erythrocytes remain nucleated
• some circulating erythrocytes undergo mitosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory