Phenotypes Associated with This Genotype

Genotype
MGI:5436107

• Allelic Composition: Etl4^tm1(cre)Kymm/Etl4⁺; Tg(CAG-EGFP-CAT-DTA)2Masa/0
• Genetic Background: involves: C3H * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality ( J:187217 )

• only 2/58 double mutant offspring are identified from crosses of cre-expressing mice with DTA-transgenic mice

skeleton

abnormal nucleus pulposus morphology ( J:187217 )

• at 8 weeks, histological analyses of caudal intervertebral disks show reductions of Safranin O-positive nucleus pulposus cells compared to wild-type

behavior/neurological

behavior/neurological phenotype ( J:187217 )

N • double mutants display no gait or behavioral abnormalities through sexual maturation