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Phenotypes Associated with This Genotype
Genotype
MGI:5435902
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response
decreased interleukin-13 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
decreased interleukin-5 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice fail to expel the helminth Nippostrongylus brasiliensis

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory