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Phenotypes Associated with This Genotype
Genotype
MGI:5435892
Allelic
Composition		 Vegfatm2Gne/Vegfatm2Gne
Tg(Csf1r-cre/Esr1*)1Jwp/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Csf1r-cre/Esr1*)1Jwp mutation (1 available)
Vegfatm2Gne mutation (1 available); any Vegfa mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased metastatic potential ( J:186831 )
• after tamoxifen-induced recombination to ablate Vegfa in cultured bone marrow-derived macrophages, the BMDMs are unable to promote trans-endothelial migration of tumor cells or enhance permeability of the endothelial monolayer, both important for metastasis
• adoptive transfer of Vegfa-null monocytes infiltrate lung metastases comparably to wild-type inflammatory monocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory