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Phenotypes Associated with This Genotype
Genotype
MGI:5435676
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Myf5tm3(cre)Sor/Myf5+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (3 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 11% die before 20 weeks of age even with special feeding (J:187144)
• remainder are dead or euthanized by 35 weeks (J:187144)
• 11% die before 20 weeks of age even with special feeding (J:187144)
• remainder are dead or euthanized by 35 weeks (J:187144)

growth/size/body
• significantly under weight (J:187144)
• combined gastrocnemius and soleus weight is low (J:187144)
• significantly under weight (J:187144)
• combined gastrocnemius and soleus weight is low (J:187144)

muscle
• moderate to severe dystrophic features in the iliopsoas muscle at 20 weeks (J:187144)
• moderate to severe dystrophic features in the iliopsoas muscle at 20 weeks (J:187144)

homeostasis/metabolism
• elevated at 4 and 8 weeks (J:187144)
• elevated at 4 and 8 weeks (J:187144)

behavior/neurological
• forelimb grip strength is reduced (J:187144)
• forelimb grip strength is reduced (J:187144)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory