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Phenotypes Associated with This Genotype
Genotype
MGI:5435674
Allelic
Composition
Fktntm1Kcam/Fktntm1Kcam
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Kcam mutation (1 available); any Fktn mutation (3 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• iliopsoas muscle from mice treated with tamoxifen show indications of dystrophic disease (J:187144)
• variations in fiber size (J:187144)
• necrosis (J:187144)
• increase in centrally nucleated fibers (J:187144)
• iliopsoas muscle from mice treated with tamoxifen show indications of dystrophic disease (J:187144)
• variations in fiber size (J:187144)
• necrosis (J:187144)
• increase in centrally nucleated fibers (J:187144)

homeostasis/metabolism
• levels begin to rise at 14 weeks of age and are significantly elevated at 16-20 weeks after tamoxifen treatment at 10 weeks of age (J:187144)
• levels begin to rise at 14 weeks of age and are significantly elevated at 16-20 weeks after tamoxifen treatment at 10 weeks of age (J:187144)

growth/size/body
N
• normal body weight at 4- 20 weeks of age after tamoxifen treatment (J:187144)
• normal body weight at 4- 20 weeks of age after tamoxifen treatment (J:187144)

behavior/neurological
N
• normal forelimb grip strength at 4-20 weeks of age after tampxifen treatment (J:187144)
• normal open field activity at 4-20 weeks of age after tampxifen treatment (J:187144)
• normal forelimb grip strength at 4-20 weeks of age after tampxifen treatment (J:187144)
• normal open field activity at 4-20 weeks of age after tampxifen treatment (J:187144)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory