Phenotypes Associated with This Genotype

Genotype
MGI:5435565

• Allelic Composition: Porcn^tm1.1Vdv/Porcn⁺; Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺
• Genetic Background: involves: 129S/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Open neural tube and abdominal wall closure defect in Porcn^tm1.1Vdv/Porcn⁺ Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:186934 )

♀ • most die before E12.5

prenatal lethality, complete penetrance ( J:186934 )

♀

embryo

caudal body truncation ( J:186934 )

♀ • axial/tail truncation in most embryos

embryonic growth retardation ( J:186934 )

♀ • become progressively smaller compared to wild-type controls

open neural tube ( J:186934 )

♀ • in most embryos

growth/size/body

embryonic growth retardation ( J:186934 )

♀ • become progressively smaller compared to wild-type controls

abnormal ventral body wall morphology ( J:186934 )

♀ • defects in ventral body wall closure in most embryos

nervous system

open neural tube ( J:186934 )

♀ • in most embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal dermal hypoplasia		DOID:2120	OMIM:305600	J:186934