Phenotypes Associated with This Genotype

Genotype
MGI:5433577

• Allelic Composition: Esr1^tm1.1Gust/Esr1^tm1.1Gust
• Genetic Background: B6.129X1-Esr1^tm1.1Gust

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

ovary hemorrhage ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

absent corpus luteum ( J:186230 )

♀

absent mature ovarian follicles ( J:186230 )

♀

hemorrhagic ovary cyst ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

uterus hypoplasia ( J:186230 )

♀ • rudimentary at 10 weeks of age and severely hypoplastic at 1 year of age

female infertility ( J:186230 )

♀

male infertility ( J:186230 )

♂

growth/size/body

hemorrhagic ovary cyst ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

increased body weight ( J:186230 )

♀ • significant in females at 4 months of age and increases with age

obese ( J:186230 )

♀ • females

homeostasis/metabolism

increased circulating glucose level ( J:186230 )

♀ • basal blood levels are increased in females

cardiovascular system

ovary hemorrhage ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

endocrine/exocrine glands

ovary hemorrhage ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

abnormal mammary gland development ( J:186230 )

♀ • ductal elongation fails to reach the lymph nodes at 7 weeks of age

absent corpus luteum ( J:186230 )

♀

absent mature ovarian follicles ( J:186230 )

♀

hemorrhagic ovary cyst ( J:186230 )

♀ • hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

integument

abnormal mammary gland development ( J:186230 )

♀ • ductal elongation fails to reach the lymph nodes at 7 weeks of age