Analysis Tools
mortality/aging
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• mice die 2 days after weaning when they receive a standard diet
• mice fed a glucose-galactose-free diet then transferred to standard chow die within 7 to 12 days
• however, mice fed a diet lacking free monosaccharides and disaccharides exhibit normal survival
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homeostasis/metabolism
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• after glucose gavage
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• mice exhibit reduced glucose triggered glucose-induced secretion of insulintropic hormone and glucagon-like peptide compared with wild-type mice
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• after glucose gavage
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• mice exhibit reduced renal proximal tubule reabsorption of filtered D-glucose compared with wild-type mice
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• in male mice
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digestive/alimentary system
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• mice fed a standard diet exhibit distended small and large intestines unlike wild-type mice
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• mice fed a standard diet exhibit distended small and large intestines unlike wild-type mice
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• phlorizin-inhibitable uptake of glucose is inhibited in the brush border membrane of the small intestine compared with wild-type mice
• sodium-D-glucose co-transport across the small intestinal brush border membrane is absent
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renal/urinary system
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• mice exhibit reduced renal proximal tubule reabsorption of filtered D-glucose compared with wild-type mice
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• in male mice
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