Phenotypes Associated with This Genotype

Genotype
MGI:5433310

• Allelic Composition: Plac1^{tm1(KOMP)Vlcg}/Plac1^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Plac1^{tm1(KOMP)Vlcg}
• Cell Lines: 10766D-E3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Expanded spongiotrophoblast layer in Plac1^{tm1(KOMP)Vlcg}/Plac1⁺ and Plac1^{tm1(KOMP)Vlcg}/Plac1^{tm1(KOMP)Vlcg} placenta

mortality/aging

postnatal lethality, complete penetrance ( J:186550 )

♀ • no females found (only 3 litters examined)

embryo

increased trophoblast giant cell number ( J:186550 )

♀

increased spongiotrophoblast size ( J:186550 )

♀ • expanded

increased placenta weight ( J:186550 )

♀ • at all time points examined compared to wild-type controls

♀ • however, weight is less than that of heterozygous mice with a maternally inherited allele at E15.5 and E16.5

abnormal placenta development ( J:186550 )

♀ • continue to increase in weight after E16.5