Phenotypes Associated with This Genotype

Genotype
MGI:5433298

• Allelic Composition: Fgf13^tm1Xuzh/Y; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:186253 )

♂ • mice exhibit impaired hippocampal development compared with wild-type mice

♂ • however, positioning of hippocampal neurons is normal by P30

abnormal dentate gyrus morphology ( J:186253 )

♂ • mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice

♂ • the dentate gyrus exhibit increased neuron numbers in the polymorphic layer compared with in wild-type mice

abnormal cerebellar granule cell morphology ( J:186253 )

♂ • mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice

abnormal neuron morphology ( J:186253 )

♂ • neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells

abnormal cerebral cortex pyramidal cell morphology ( J:186253 )

♂ • at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice

♂ • mice exhibit more loosely arrayed neurons with irregular inner and outer borders in the C1 pyramidal layer compared to in wild-type mice

decreased neuron number ( J:186253 )

♂ • reduced Cux1+ cells

♂ • however, the number of Cux1+ neurons are normal at P14 and during adulthood

increased neuron number ( J:186253 )

♂ • Tbr1+ neurons in the deep layer is increased compared to in wild-type mice

behavior/neurological

abnormal spatial learning ( J:186253 )

♂ • in a Morris water maze

abnormal spatial working memory ( J:186253 )

♂ • in a Morris water maze