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Phenotypes Associated with This Genotype
Genotype
MGI:5433107
Allelic
Composition		 Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (75 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Scgb1a1tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system development ( J:185603 )
• mice exhibit an increase in goblet cell differentiation compared with control mice
abnormal respiratory system physiology ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism
increased susceptibility to injury ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory