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Phenotypes Associated with This Genotype
Genotype
MGI:5433072
Allelic
Composition
Tff1tm1Mrio/Tff1tm1Mrio
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tff1tm1Mrio mutation (0 available); any Tff1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach
• mutants develop gastric tumors

digestive/alimentary system
• mutants exhibit dysplastic lesions in the antral mucosa; dysplastic glands are lined by epithelial cells that, in contrast to controls, are crowded and overlapping, and whose nuclei show hyperchromasia, irregular nuclear contours, and pleomorphism
• antral mucosa is thickened, with disorganized, complex architecture
• stomach shows nodularity externally and polypoid, firm lesions intramucosally in a circumferential manner in the distal stomach
• mutants develop gastric tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
stomach cancer DOID:10534 OMIM:137215
OMIM:613659
J:84201


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory