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Phenotypes Associated with This Genotype
Genotype
MGI:5433031
Allelic
Composition
Gabra1tm1.1Geh/Gabra1+
Genetic
Background
D2.129(Cg)-Gabra1tm1.1Geh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra1tm1.1Geh mutation (0 available); any Gabra1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges
• Background Sensitivity: heterozygotes on a DBA/2J congenic background display an average of 19 spike wave discharge events per hour with no significant difference found between genders

nervous system
• spike wave discharges associate with behavioral arrest and treatment with ethosuximide decreases the incidence of spike wave discharges
• Background Sensitivity: heterozygotes on a DBA/2J congenic background display an average of 19 spike wave discharge events per hour with no significant difference found between genders

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
idiopathic generalized epilepsy DOID:1827 OMIM:600669
J:186685


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory