Phenotypes Associated with This Genotype

Genotype
MGI:5432935

• Allelic Composition: Ryr2^tm2.1Maya/Ryr2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:186291 )

N • at rest, mice exhibit normal cardiac morphology and function

ventricular tachycardia ( J:186291 )

• mice exhibit bidirectional or polymorphic ventricular tachycardia (VT) induced by exercise or epinephrine unlike in wild-type mice

• pretreatment with K201 (JTV519) does not affect inducible VT

• however, dantrolene treatment rescues phenotype

abnormal myocardial fiber physiology ( J:186291 )

• cardiomyocytes exhibit reduced threshold of sarcoplasmic reticulum calcium load for channel activation compared with wild-type cells