Phenotypes Associated with This Genotype

Genotype
MGI:5432926

• Allelic Composition: Ccbe1^tm1Lex/Ccbe1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:186594 )

immune system

abnormal lymphangiogenesis ( J:186594 )

• mice lack lymph sacs with few Prox1+ and Lyve1+ lymphatic endothelial cells in the cardinal vein wall compared wild-type mice

• lymphatic endothelial cells fail to migrate unlike in wild-type mice

absent lymphatic vessels ( J:186594 )

homeostasis/metabolism

edema ( J:186594 )

• from E13.5