Phenotypes for Tespa1 Tg(TcraTcrb)425Cbn MGI:5432918 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tespa1^tm1Smoc/Tespa1^tm1Smoc Tg(TcraTcrb)425Cbn/0
Genetic Background	B6.Cg-Tespa1^tm1Smoc Tg(TcraTcrb)425Cbn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1^tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraTcrb)425Cbn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:186446 )

• very few cells proceed to the CD4+ single positive stage

decreased CD4-positive, alpha-beta T cell number ( J:186446 )

• in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:186446 )

• in the periphery

hematopoietic system

abnormal T cell differentiation ( J:186446 )

• very few cells proceed to the CD4+ single positive stage

decreased CD4-positive, alpha-beta T cell number ( J:186446 )

• in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:186446 )

• in the periphery

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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