Phenotypes Associated with This Genotype

Genotype
MGI:5432528

• Allelic Composition: Cirbp^tm1Jfuji/Cirbp^tm1Jfuji
• Genetic Background: B6.129S2-Cirbp^tm1Jfuji

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:186425 )

N • mice exhibit normal fertility

decreased spermatogonia number ( J:186425 )

♂ • fewer undifferentiated spermatogonia

abnormal spermatogonia proliferation ( J:186425 )

♂ • suppression of cell cycle progression in spermatogonial cell line in vitro and undifferentiated spermatogonia in vivo

cellular

decreased spermatogonia number ( J:186425 )

♂ • fewer undifferentiated spermatogonia

abnormal cell cycle ( J:186425 )

• slower cell-cycle progression (from G0 to G1 and G1 to S phase) in mouse embryonic fibroblasts

• suppression of cell cycle progression in spermatogonial cell line in vitro and undifferentiated spermatogonia in vivo

decreased fibroblast proliferation ( J:186425 )

• of mouse embryonic fibroblasts

abnormal spermatogonia proliferation ( J:186425 )

♂ • suppression of cell cycle progression in spermatogonial cell line in vitro and undifferentiated spermatogonia in vivo