Phenotypes Associated with This Genotype

Genotype
MGI:5432337

• Allelic Composition: T(7;19)145H/?
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

azoospermia ( J:34742 )

♂ • testes and epididimi are entirely devoid of sperm

mortality/aging

mortality/aging ( J:34742 )

N • balanced translocation bearing dams produce sterile and fertile male progeny (based on testis size) at a 1:1 ratio; thus, the small litters are not due to embryonic death of balanced carriers

reproductive system

azoospermia ( J:34742 )

♂ • testes and epididimi are entirely devoid of sperm

decreased testis weight ( J:34742 )

♂ • male mice balanced for this translocation have small testes (< 50 mg)

arrest of male meiosis ( J:34742 )

♂ • from the primary spermatocyte stage onward, very few or no cells are present, indicating arrest of spermatogenesis at some point during meiosis

♂ • numbers of Sertoli cells, interstitial cells and spermatogonia are normal to the primary spermatocyte stage

reduced female fertility ( J:34742 )

♀ • female mice balanced for this translocation produce litters ~52% as large as those of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)

decreased litter size ( J:34742 )

• mean litter size of dams balanced for this translocation is ~52% that of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)

male infertility ( J:34742 )

♂ • males balanced for this translocation are sterile

endocrine/exocrine glands

decreased testis weight ( J:34742 )

♂ • male mice balanced for this translocation have small testes (< 50 mg)