Phenotypes for Pgap1 MGI:5432254 MGI Mouse

craniofacial

abnormal cranium morphology ( J:187360 )

• all elements rostral to the interparietal element and tectum synoticum are largely absent

abnormal cranial cartilage morphology ( J:187360 )

• the tectum synoticum is present as two lateral elements that do not transverse the midline

abnormal interparietal bone morphology ( J:187360 )

• interparietal element is dysmorphic and not ossified

abnormal occipital bone morphology ( J:187360 )

• the supraoccipital and exoccipital elements are not ossified but are present

absent basioccipital bone ( J:187360 )

• the basioccipital element is absent

nervous system

abnormal forebrain development ( J:187360 )

• marker analysis indicates forebrain pattern defect, including a lack of Fgf8 expression in the anterior neural ridge indicating that the anterior neural ridge fail to develop

• early forebrain organizing centers are disrupted

holoprosencephaly ( J:101977 , J:187360 )

• in E11.5 embryos (J:187360)

forebrain hypoplasia ( J:187360 )

• embryos present with anterior truncations of the head

growth/size/body

decreased fetal size ( J:187360 )

• mutants are smaller

• shortening of the femur by 10.4% and of the humerus by 5.7%

skeleton