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Phenotypes Associated with This Genotype
Genotype
MGI:5432218
Allelic
Composition		 Sod2tm1Shs/Sod2+
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6 * C57BL/6CrSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1Shs mutation (0 available); any Sod2 mutation (25 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal tubule epithelium morphology ( J:174099 )
• mice show prominent epithelial cell swelling in the dilated distal tubules

cellular
oxidative stress ( J:174099 )
• mice display a significant increase in oxidative stress (tyrosine nitration) in dilated renal tubules

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory