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Phenotypes Associated with This Genotype
Genotype
MGI:5432217
Allelic
Composition
Sod2tm1Shs/Sod2tm1Shs
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: C57BL/6 * C57BL/6CrSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1Shs mutation (0 available); any Sod2 mutation (24 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit no overt survival difference up to ~22 months of age relative to controls

growth/size/body
• at 8 weeks of age, mice exhibit a significantly smaller body weight relative to controls
• however, no significant differences in the weight of vital organs (kidney, liver, heart and lungs) are observed

renal/urinary system
N
• mice exhibit no overt decrease in renal function, as measured by serum creatinine levels
• mice show prominent epithelial cell swelling in the dilated distal tubules
• mice exhibit dilated distal tubules within the cortex region relative to controls
• dilated distal tubules show a significant increase in proteinacious casts within the tubular lumen
• acellular casts within distal tubules, collecting ducts, and Loops of Henle display positive staining for tyrosine nitration

cellular
• mice display a significant increase in oxidative stress (tyrosine nitration) in dilated renal tubules
• tyrosine nitration is detected in cortical regions (dilated distal tubules and collecting ducts) as well as medullary regions (including the collecting ducts and Loops of Henle)

homeostasis/metabolism
N
• mice exhibit normal blood glucose levels relative to controls
• no significant difference in serum creatinine levels relative to controls

cardiovascular system
N
• mice exhibit no significant change in systolic blood pressure relative to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory