Analysis Tools
mortality/aging
| N |
• mice exhibit no overt survival difference up to ~22 months of age relative to controls
|
growth/size/body
|
• at 8 weeks of age, mice exhibit a significantly smaller body weight relative to controls
• however, no significant differences in the weight of vital organs (kidney, liver, heart and lungs) are observed
|
renal/urinary system
| N |
• mice exhibit no overt decrease in renal function, as measured by serum creatinine levels
|
|
• mice show prominent epithelial cell swelling in the dilated distal tubules
|
|
• mice exhibit dilated distal tubules within the cortex region relative to controls
|
renal cast
(
J:174099
)
|
• dilated distal tubules show a significant increase in proteinacious casts within the tubular lumen
• acellular casts within distal tubules, collecting ducts, and Loops of Henle display positive staining for tyrosine nitration
|
cellular
|
• mice display a significant increase in oxidative stress (tyrosine nitration) in dilated renal tubules
• tyrosine nitration is detected in cortical regions (dilated distal tubules and collecting ducts) as well as medullary regions (including the collecting ducts and Loops of Henle)
|
homeostasis/metabolism
| N |
• mice exhibit normal blood glucose levels relative to controls
• no significant difference in serum creatinine levels relative to controls
|
cardiovascular system
| N |
• mice exhibit no significant change in systolic blood pressure relative to controls
|
