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Phenotypes Associated with This Genotype
Genotype
MGI:5432190
Allelic
Composition
Tg(YAC128)55Hay/Tg(YAC128)55Hay
Genetic
Background
FVB/N-Tg(YAC128)55Hay
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)
• decrease in striatal volume at 12 months of age (J:105723)
• decrease in striatal volume at 12 months of age (J:105723)
• at 18 months of age in the striatum and cortex (J:105723)
• at 18 months of age in the striatum and cortex (J:105723)

behavior/neurological
• beginning at 4 months of age and becoming worse with age (J:105723)
• disease progression is slower than in mice hemizygous forTg(YAC128)53Hay but faster than in hemizygous mice (J:105723)
• beginning at 4 months of age and becoming worse with age (J:105723)
• disease progression is slower than in mice hemizygous forTg(YAC128)53Hay but faster than in hemizygous mice (J:105723)
• approaches statistical significance at 12 months of age (J:105723)
• approaches statistical significance at 12 months of age (J:105723)

cellular
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• general increase in stress-induced apoptosis in primary cultures of striatal neurons (J:105728)
• in cultured striatal medium spiny neurons in response to mitochondria stress (J:105728)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)

homeostasis/metabolism
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in medium spiny neurons in response to NMDA (500 um) exposure compared to wild-type and mice hemizygous for this transgene (J:105723)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)
• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176 (J:105728)
• apoptosis induced by KCl alone is greater than in mice homozygous for Tg(YAC72)2511Hay (J:105728)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:105723 , J:105728


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory