Phenotypes Associated with This Genotype

Genotype
MGI:5432176

• Allelic Composition: Gt(ROSA)26Sor^{tm48(HTT)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:243843 )

• mice live for a median period of 204 days

behavior/neurological

impaired coordination ( J:243843 )

• mice exhibit impaired rotarod performance at 4 months of age and perform significantly more poorly at 6 months of age compared to the other lines

decreased vertical activity ( J:243843 )

• mice show reduced rearing at 4 and 5 months of age, with the greatest reduction compared to the other lines

decreased locomotor activity ( J:243843 )

• mice show reduced number of floor plan moves in the open field at 5 months of age

nervous system

abnormal medium spiny neuron morphology ( J:243843 )

• expression of DARPP-32, a maker of medium spiny neurons, in the striatum is reduced in 4 month old mice

nervous system inclusion bodies ( J:243843 )

• striatum and cortex exhibit aggregation of HTT at 4 months of age indicating neuronal pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:243843