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Phenotypes Associated with This Genotype
Genotype
MGI:5432136
Allelic
Composition		 Apctm2.1Cip/Apc+
Lrig1tm1.1(cre/ERT2)Rjc/Lrig1+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Cip mutation (2 available); any Apc mutation (154 available)
Lrig1tm1.1(cre/ERT2)Rjc mutation (1 available); any Lrig1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:186084 )
• with tamoxifen treatement, colon tumors are observed by day 50 following Apcfldeletion with cre induction (and stochastic loss of second Apc allele)
• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant
• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum

digestive/alimentary system
increased intestinal adenoma incidence ( J:186084 )
• with tamoxifen treatement, colon tumors are observed by day 50 following Apcfldeletion with cre induction (and stochastic loss of second Apc allele)
• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant
• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory