Phenotypes Associated with This Genotype

Genotype
MGI:5432135

• Allelic Composition: Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺; Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1^{tm1.1(cre/ERT2)Rjc}
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:186084 )

• at 5-6 months, nearly 90% of mice develop duodenal tumors (usually low grade adenomas)

• in one instance, a 13-month old mouse had a tumor with areas showing high grade dysplasia, and focal extension of neoplastic glands into deeper layers of the bowel wall; tumor showed intact Apc however

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:186084 )

• number of crypts showing Lgr5-EGFP fluorescence is doubled in absence of Lrig1 protein, compared to mice with one or two copies of Lrig1

increased intestinal adenoma incidence ( J:186084 )

• at 5-6 months, nearly 90% of mice develop duodenal tumors (usually low grade adenomas)

• in one instance, a 13-month old mouse had a tumor with areas showing high grade dysplasia, and focal extension of neoplastic glands into deeper layers of the bowel wall; tumor showed intact Apc however

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:186084 )

• number of crypts showing Lgr5-EGFP fluorescence is doubled in absence of Lrig1 protein, compared to mice with one or two copies of Lrig1