Phenotypes Associated with This Genotype

Genotype
MGI:5432104

• Allelic Composition: Grin2b^tm1Mony/Grin2b^tm1Mony; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:186311 )

• mice exhibit impaired egocentric spatial memory acquisition compared with control mice

abnormal discrimination learning ( J:186311 )

• impaired visual discrimination learning

abnormal object recognition memory ( J:186311 )

• impaired

abnormal spatial learning ( J:186311 )

• impaired in a Morris water maze

abnormal spatial reference memory ( J:186311 )

• impaired in a Morris water maze and appetitive, elevated Y maze

abnormal spatial working memory ( J:186311 )

• impaired in a discrete trial, spontaneous alternation paradigm in an enclosed T maze or a reward alternation on an elevated T maze

decreased anxiety-related response ( J:186311 )

• more so than in Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-Grin2c/itTA)12Rps Tg(tetO-cre)LC1Bjd mice

abnormal motor coordination/balance ( J:186311 )

• improved performance on a rotarod

hyperactivity ( J:186311 )

• more so than in Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-Grin2c/itTA)12Rps Tg(tetO-cre)LC1Bjd mice

nervous system

nervous system phenotype ( J:186311 )

N • mice exhibit normal cortical layer 4 whisker barrel structures and paired-pilse facilitation

abnormal excitatory postsynaptic currents ( J:186311 )

• ifenprodil-treated mice fail to exhibit an acceleration of NMDAR-mediated excitatory postsynaptic currents compared with wild-type mice

abnormal excitatory postsynaptic potential ( J:186311 )

• at high stimulation frequency, mice exhibit smaller maximal depolarization of the excitatory postsynaptic potentiation (EPSP) envelop and EPSP integral compared with control mice

• however, mice exhibit normal input resistance, action potential threshold, firing pattern and maximal firing frequency

abnormal NMDA-mediated synaptic currents ( J:186311 )

• mice fail to exhibit a reduction in NMDA currents in response to the Grin2b antagonist ifenprodil unlike control mice

• mice exhibit a faster deactivation kinetics (weighted tau) compared with control mice

• ifenprodil-treated mice fail to exhibit an acceleration of NMDAR-mediated excitatory postsynaptic currents compared with wild-type mice

reduced long-term potentiation ( J:186311 )

• low-frequency synaptic stimulation long term potentiation is reduced compared to in control mice

• during long term potentiation induction, charge transfer is reduced compared to in control mice

abnormal miniature excitatory postsynaptic currents ( J:186311 )

• miniature excitatory postsynaptic current amplitudes 50 ms are attenuated after onset unlike in control mice

growth/size/body

decreased body weight ( J:186311 )

• slightly