Phenotypes for Epas1 Hif1a Tg(Sp7-tTA,tetO-EGFP/cre)1Amc Vhl MGI:5432005 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Epas1^tm1Mcs/Epas1^tm1Mcs Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Vhl^tm1Jae/Vhl^tm1Jae Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epas1^tm1Mcs mutation (1 available); any Epas1 mutation (66 available)
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased trabecular bone volume ( J:186085 )

decreased bone trabecula number ( J:186085 )

hematopoietic system

hematopoietic system phenotype ( J:186085 )

N	• mice exhibit normal frequencies of KLS cells (hematopoietic stem cells and multipotential progenitors) numbers of red blood cells and lymphocytes and hematocrit

homeostasis/metabolism

decreased circulating erythropoietin level ( J:186085 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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